The Global Burden of Disease Study 2010 (GBD 2010), estimated that a substantial proportion of the world’s disease burden came from mental, neurological and substance use disorders. In this paper, we used GBD 2010 data to investigate time, year, region and age specific trends in burden due to mental, neurological and substance use disorders.
During puberty, when young people are completing their education, transitioning into employment, and forming
longer-term intimate relationships, a shift in emotional regulation and an increase in risky behaviour, including
substance use, is seen. This Series paper considers the potential eff ects of alcohol, tobacco, and illicit drug use during
this period on: social, psychological, and health outcomes in adolescence and young adulthood; role transitions, and
later health and social outcomes of regular substance use initiated in adolescence; and the off spring of young people
who use substances.